Furio, boss man, the conquest of the American Indians took over a hundred years and the first conflicts were with muskets and hand to hand combat. Most people think of the Plains Indians like Sitting Bull and Crazy Horse but their were many great Indian leaders before them like Tecumseh in 1812. I attached a scene from Last of the Mohicans, if you want to view it, so you can better understand the conflict between settlers and natives. The Gatling Gun(machine gun) didn't come out until 1863 but was hardly ever used against the Plains Indians due to their mobility. It was extremely difficult to haul around a heavy galling gun on the dry alkali Plains out west.