The best evidence points toTony Palazzolo and Billy Giacalone (plus another man, probably Bozzi Vitale or Jimmy Quasarano) picking him up from the Red Fox. He was then driven to a nearby home linked with the mob. It would be a home he had sit-downs before with some of the same characters. This would ensure the location did not raise any suspicions, as Hoffa always had his guards up.

Over the preceding months, Hoffa had multiple meetings with mobs figures that were arranged by the Giaclone brothers. The GR reported up to 12 of such meetings took place. Hoffa must have thought he was going to one of those routine meetings.

As for as Palazzolo, he was caught on wiretap talking about the Hoffa murder and the Central Sanitation links place Vitale and Quasarano right in the middle of the conspiracy. Furthermore, Quasarano and Vitale headed a meeting with top level NY mobsters (including Briguglio who was also present) in Manhattan to brief them on what happened a few days after the murder.

Once Hoffa entered the residence one of those present either shot him or he was strangled by the three men who picked him up. They then destroyed the body, most likely using sanitation facilities many of which were accessible to the mob. FBI informants at the time reported that over 10 mob victims were known to have been subject to the same treatment.

Due to the intense scrutiny the murder would be expected to bring about, the Detroit mob had the foresight to completely get rid of Hoffa's body.