It's gotta be Kansas City. By the way, I give zero credit to law enforcement or RICO for the extinction of any Families. It all comes down to demographics and the lack of a recruitment pool plus just an overall lack of criminal opportunities to exploit anymore in many major cities that once housed LCN.
I agree with that along with the decline of the "Italian neighborhood" which were breeding grounds as well as the decline of social clubs. Social clubs were a place to get noticed as strange as that sounds. Every young aspiring mobster found his way to a social club.