I think Trafficante. Santo was big in Cuba, as big or even bigger than Meyer Lanksy. He was at the center of the anti-Castro efforts by the CIA and the mob. He was huge in heroin, in fact he traveled directly to Asia to open up that pipeline(another joint CIA/mob venture). And even though he had a small family he had a lot of people/territory under his umbrella, he ran numbers with the "cracker mob", bolita and drugs with the first wave(pre-Mariel) Cubans etc.

No way to compare them when it comes to money because it's impossible to know how much they made*other than the absurd $2 billion/year figure from the Marcello book) but in terms of status the things I mentioned above give Santo the edge on the national stage.