Luigi Nicholas Mangione is the heir to a wealthy and famous Maryland family. The patriarch, Nicholas Mangione, born in Baltimore's Little Italy, passed away in 2008 at the age of 83, leaving behind a real estate empire that included golf clubs and media. His grandfather owned the Turf Valley Resort and Hayfields Country Club, two luxury resorts with a hotel, restaurant, and pool, all surrounded by acres of woods, as well as the radio station WCBM-AM.

Luigi's cousin is politician Nino Mangione, a Republican member of the Maryland House of Delegates. His mother, Kathleen Zannino Mangione, owns a travel agency specializing in Mediterranean travel. The family lives in Towson, Maryland.