They just had a short segment on CNN this morning regarding Season six. According to the reporter, "something big is gonna happen, and it'll be in the last 3 minutes of the show.

They interviewed breifly many of the co-stars, and they all said they can not tell. Tony Sirico (Paulie) said "there'll be a lot of surprises...underline surprises". I love the build-up. Looking forward to it.
Don't leave the couch the last three minutes of the show.
TIS
Just a reminder for whomever starts a thread on the first episode....remember to put spoiler in the topic. I don't know about everyone else, but I hate to know what's gonna happen. Ok, I'm curious, but still like to be surprise. :p