It would be impossible for the mob to take on the Los Zetas, MS-13, Sinaloa Cartel, etc.
I'd take any of the Five Families against a local MS-13 gang. The Sinaloa and Los Zetas cartels are based in Mexico so there's no reason for them to kill a Mafia boss.
"I die outside; I die in jail. It don't matter to me," -John Franzese
