This question is subjective; least damaged as in from general attrition or least damaged as in from prosecution?
Prosecution; I'd argue Detroit, simply because the family's small size has made it less of a law enforcement, particularly from the FBI, target.
General Attrition; arguably one of the 3 smaller New York Families.
"The Feds are a business Anthony, millions of tax dollars are invested in watching your ass, sooner or later, just like you, their gonna want a return on their investment." --- Neil Mink, Tony Soprano's lawyer
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